While many ergonomic mice are right-handed, you can find models with dedicated left-handed or ambidextrous designs, though they may be more expensive. I’ve gathered a list of the best ergonomic mice available and broken down their features to help you find the best one that fits you and your work style.
The Logitech MX Vertical is one of the most well-rounded, and best-designed ergonomic mice on the market. Its vertical design puts your hand and forearm into a more natural, handshake-like position to reduce muscle and tendon strain during long days at the computer. The optical sensor has a max DPI of 4,000 for speed and precision, and the conveniently placed DPI switch button lets you choose the sensitivity that best suits your work. Each of the 4 buttons can be programmed for different hotkey inputs or tasks, simplifying your workflow.  It’s compatible with just about every operating system, and you can connect the mouse to up to three devices at once, switching between them with the push of a button or simply by moving the cursor to the next screen with the Logitech Flow program. The mouse connects to your computer via USB dongle, USB-C cable, or Bluetooth. The rechargeable battery gives you up to 4 months of use on a full charge, and just one minute of charging gives you 3 hours of use – which is perfect for when you forget to charge overnight or need a quick top-up before a presentation. You don’t have to spend a ton of money to get an ergonomic mouse for your workspace. Cherry, the same company that makes mechanical keyboard switches, has developed an affordable, vertical mouse to help reduce hand, wrist, and forearm strain. The 45-degree angle puts your arm in a more natural position to reduce stress on your muscles and tendons as well as put each of the 6 buttons within easy reach.  The optical sensor has a max DPI of 1200, and you can choose between three different sensitivity levels with the DPI selector button. The mouse runs on two AAA batteries, and it can last up to 6 months before you need to even think about finding more batteries. An LED indicator lets you know well ahead of time when your batteries are getting a bit low. It also comes in a left-handed configuration. Long gone are the days when a trackball mouse looks like some sort of modern art installation. The ProtoArc EM01 has a traditional, right-handed mouse design that places the cursor trackball at your thumb for more comfortable navigation. The optical sensor has a max DPI of 2,400, and you can select different levels of sensitivity with the thumb buttons to suit your work. You can also adjust the tilt angle of your mouse up to 20-degrees for a more natural hand and arm placement. It takes some getting used to, but once you get a feel for how the trackball works, gaming with the EM01 feels as natural as it does with a traditional mouse. The integrated battery lasts up to 100 days on a single charge and can be recharged by connecting the mouse to your computer via a USB-C cable. The ProtoArc EM01 is also capable of controlling two different devices simultaneously with Bluetooth connectivity. Just press the wireless mode selector button to switch between computers. And if you want to show off a little of your personal style, the mouse has an RGB ring light around the trackball that can be programmed with over 16 million colors and 4 lighting effects. We lefties tend to get forgotten or outright ignored when it comes to computer peripherals, but Evoluent has designed an ergonomic mouse just for us. It has a vertical design to put your hand and arm in a more natural position as well as to keep all of the 6 buttons within easy reach. You can also program each of the buttons to perform a specific task or set them as hotkeys for actions within programs. The laser sensor has 4 different DPI levels, which you can switch between with the push of a button and see which level you have selected with the handy LED indicator. Mac users aren’t left behind when it comes to ergonomic mice. The Apple Magic Mouse features a sleek, ambidextrous design that works well in either hand and a curved surface that fits the palm for more comfortable long-term use. The top of the mouse also supports touch-based inputs for scrolling, zoom, and swiping. The internal battery gives you up to 8 weeks of use on a full charge, so you can spend more time working and less time worrying about powering your new mouse.  You’ll also want to consider a mouse that lets you program both DPI sensitivity and button layouts for more efficient workflow and better accuracy if you deal with spreadsheets. If you want to eliminate all hand, wrist, and arm movements to alleviate severe discomfort, consider a stationary trackball model, which uses a rolling sphere to move the cursor rather than a mouse sensor. They do take some getting used to, so give yourself time to learn how your trackball mouse works before using it on important projects.